Endocrine Abstracts

Objectives: Ultrasound-guided fine needle aspiration biopsy (FNAB) is a commonly performed diagnostic procedure for evaluation of thyroid nodules. The Bethesda System for Reporting Thyroid Cytopathology comprises six categories. Bethesda categories I and III present a challenge for deciding on further diagnostic and therapeutic procedures. Category I includes non-diagnostic or unsatisfactory results that may be due to both aspiration of cystic material from simple cysts or asp...

Introduction: According to modern studies, hypercalcemia is associated with an increased risk of urolithiasis, cholelithiasis, gastritis and peptic ulcer.Objective: To study the prevalence of urolithiasis, cholelithiasis, gastritis and peptic ulcer in patients with hypercalcemia in Minsk-city.Materials and methods: we studied 1207 people, average age 53.9±17.25 (892 women, 315 men) from 18 to 96 years. Examination: total calci...

Background and aims: Diabetic nephropathy is one of the most prevalent and dangerous chronic complication of diabetes mellitus. Its end-stage, renal chronic failure is the most important cause of premature death in diabetic patients. Microalbuminuria (MA), one of the first signs of diabetic nephropathy, may be present from the moment of diagnosis in type 2 diabetes. The aim of our study was to determine the prevalence of microalbuminuria and to identify predictor factors in a ...

The immunosuppressive effect of corticosteroids is well known. In some circumstances prophylactic antibiotic therapy is routinely used to lower the risk of opportunistic infections in immunocompromised patients with exogenous hypercortisolemia. The incidence of opportunistic infection in endogenous hypercortisolemia in Cushing’s syndrome is 11–17%, correlating with degree of hypercotisolemia. Only several case reports have been published about pneumocystis pneumonia ...

Objective: Treatment with ergot-derived dopamine agonists, pergolide and cabergoline, has been associated with an increased frequency of valvular heart disease in Parkinson’s disease. The aim of the present study was to assess the prevalence of valvular heart disease in patients treated with dopamine agonists for prolactinomas.Design: Cross-sectional study.Patients: We performed conventional two-dimensional and Doppler echocar...

Growth hormone (GH) responsive cells are extensively distributed in central nervous system, including in neurons of the arcuate (ARH) and ventromedial nucleus (VMH) of hypothalamus, areas that control food intake, energy expenditure and blood glucose. During metabolic stresses, such as food restriction and hypoglycemia, GH secretion is stimulated and may be important to maintain survival. In the present study, we first verified that an acute GH injection stimulates food intake...

Background: The clinical presentation of non-functioning pituitary adenomas (NFAs) can range from an incidental finding on imaging to pituitary hormone deficiencies and visual compromise.Objective: To assess the clinical presentation of patients who had undergone surgical resection of histologically proven NFAs.Methods: Patients presenting to the University Hospital of Wales, Cardiff, with non-functioning pituitary adenomas (histol...

Introduction: For the last 2 years we have been giving regular diabetes education sessions in conjunction with our hospital school, based around maths skills. These went well, but we wanted to develop these further, making them more patient centred. We gained a grant from the Diabetes Research and Wellness Foundation and designed a 4 day programme with ‘The Puppet Project’ and ‘WAC arts’. This was done very much in collabaration with our hospital school who...

Current therapies for locally advanced or metastatic prostate cancer aim to inhibit androgen receptor (AR) activation directly or by depleting androgens via androgen deprivation therapy. However this therapeutic approach eventually fails in ~80% of patients, leading to development of castrate resistant prostate cancer (CRPC). There are currently few therapeutic options available for CRPC with limited prognostic or predictive biomarkers. The aim of the current study was to dete...

A 35-year old female presented with a 5 day history of headache, diplopia and reduced visual acuity preceded by 6 months of lethargy and weight gain. Visual field testing revealed left temporal hemianopia. Magnetic resonance imaging (MRI) showed a benign pituitary adenoma with intra-tumoural haemorrhage compressing the optic chiasm. Neurosurgical opinion advised on transphenoidal surgery. However, in view of spontaneous resolution of diplopia and recovery of peripheral vision,...